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- Season 1 1993-08-30
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- Season 22 2014-09-02
Season 22 Episode
- Season 22 Luke Wilson, Julie Chen, Lee Brice
- Season 22 Kristen Wiig, Sen. Elizabeth Warren, The New Pornographers
- Season 22 Steve Buscemi, Indy Car Season Champ, Alt-J
- Season 22 Tina Fey, Moody McCarthy, Kevin Drew
- Season 22 Bill Maher, Henrik Lundqvist, Spoon
- Season 22 Michael Strahan, Richard Branson, Interpol
- Season 22 Dr. Phil, Katharine McPhee, Death from Above 1979, Ray Benson
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- Season 22 Mindy Kaling, Jake Johannsen, Maddie & Tae
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- Season 22 John Oliver, Maggie Q, Bleachers
- Season 22 Bill O'Reilly, Cristin Milioti
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- Season 22 Mariska Hargitay, Simon Amstell, Kandace Springs
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- Season 22 Robert Downey Jr., Sarah Paulson, Lizzo
- Season 22 Anderson Cooper, Gina Rodriguez, Hatsune Miku
- Season 22 Robert Duvall, Elle Fanning, Rival Sons
- Season 22 Chelsea Handler; Keegan-Michael Key and Jordan Peele; Angaleena Presley
- Season 22 Russell Brand, Dave Grohl, Foo Fighters
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- Season 22 Bill Murray, Foo Fighters
- Season 22 Tom Selleck, Jenny Slate, Foo Fighters
- Season 22 Jessica Chastain, Lenny Marcus, Foo Fighters
- Season 22 Amy Poehler, Sen. Jeff Flake, Sen. Martin Heinrich, Mastodon, Jerry Lee Lewis
- Season 22 Taylor Swift, Tom Mison
- Season 22 Jim Carrey, David Tennant
- Season 22 Brian Williams, Perfume Genius
- Season 22 Keith Olbermann, Brian Regan, Run the Jewels
- Season 22 Martin Short, Father John Misty
- Season 22 Jennifer Lopez, Rob Riggle, Kimbra
- Season 22 Whoopi Goldberg, Jimmy Page, Mapei
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- Season 22 Katie Holmes, Alex Zanardi
- Season 22 Steve Carell, Martha Stewart, OK Go
- Season 22 Jennifer Lawrence, Boris Johnson
- Season 22 Jon Stewart, Shawn Mendes
- Season 22 Kristin Chenoweth; Chris Young
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- Season 22 Regis Philbin, Hundred Waters
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- Season 22 Norman Lear, TV on the Radio
- Season 22 Seth Rogen, Amy Sedaris
- Season 22 Emily Blunt, Adam Resnick, Wu-Tang Clan
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- Season 22 Meryl Streep, Rebel Wilson, J. Cole
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- Season 22 Jamie Foxx, Robert Klein, Dan Penn
- Season 22 Emma Stone Top, Marcus Mariota, Bob Seger
- Season 22 New Holiday Toys, Anna Kendrick, Charli XCX
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- Season 22 Rosie O’Donnel,l Jeff Altman
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- Season 22 Ethan Hawke, Allison Williams, Parquet Courts
- Season 22 Julianne Moore, Catfish & the Bottlemen
- Season 22 Donald Trump, Chelsea Peretti, Foxygen
- Season 22 Michael Somerville, Nicole Atkins
- Season 22 Gordon Ramsay, Adam Devine, St. Paul and the Broken Bones
- Season 22 Anderson Cooper, Shovels & Rope
- Season 22 Amanda Peet, Ryn Weaver
- Season 22 Larry David, Dan Patrick, Sleater-Kinney
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- Season 22 Louis CK, Nicolle Wallace, the Lone Bellow
- Season 22 Andrew Luck, Oscar Isaac, Drenge
- Season 22 Viola Davis, Ben Schwartz, Marty Stuart
- Season 22 John Oliver, Mayim Bialik, Death Cab for Cutie
- Season 22 Aziz Ansari, Brian Kiley, Ben Howard
- Season 22 Jack Hanna, Sharon Jones and the Dap-Kings
- Season 22 Dr. Phil McGraw, Robin Tunney, Diana Krall
- Season 22 Ryan Reynolds, Dierks Bentley
- Season 22 Martin Short, Bettye Lavette
- Season 22 Sienna Miller, Andy Kindler, Bob Mould
- Season 22 Steve Carell, Dr. Cornel West
- Season 22 Courtney Love, Chris Elliott, Rhiannon Giddens
- Season 22 Bill Belichick, Elisabeth Moss, Madisen Ward and the Mama Bear
- Season 22 Tom Hanks, Sturgill Simpson
- Season 22 Bill Hader, Pat McGann, Shakey Graves
- Season 22 Matthew Perry, Adam Scott, Kishi Bashi
- Season 22 Dakota Johnson, David Tochinskiy, Twin Shadow
- Season 22 Will Smith, Grizfolk
- Season 22 Don Cheadle, Ilana Glazer & Abbi Jacobson, Mikky Ekko
- Season 22 Kid Scientists, Sean Hayes, Judah & the Lion
- Season 22 Helen Mirren, the 2015 Daytona 500 winner, Steve Earle
- Season 22 Matthew Broderick, Ellie Kemper, JD McPherson
- Season 22 Julianna Margulies, Eric Ripert, Glass Animals
- Season 22 Kevin Spacey, Lily James, Alabama Shakes
- Season 22 Patricia Arquette, Will Butler
- Season 22 Kelsey Grammer, Stevie Wonder
- Season 22 Lena Dunham, Bobby Cannavale, Andy Kim with Kevin Drew
- Season 22 Kevin Bacon, Jimmie Walker, Airborne Toxic Event
- Season 22 Shailene Woodley, Dr. Cornel West, Matthew E. White
- Season 22 Will Ferrell, Glen Hansard
- Season 22 Norm MacDonald, Theo James
- Season 22 Ben Stiller, Tove Lo
- Season 22 Bill O'Reilly, Aubrey Plaza
- Season 22 James Franco, Jake Johannsen, Action Bronson
- Season 22 Neil Patrick Harris, Charlie Cox, the Suffers
- Season 22 David Duchovny, Josh Gad, Houndmouth
- Season 22 Sen. Al Franken, Billy Eichner, David Sanborn
- Season 22 Kelly Ripa, Aasif Mandvi, Fat White Family
- Season 22 Mike Myers, Nick Griffin, Banks
- Season 22 Sarah Jessica Parker, Julie Chen, Asleep at the Wheel
- Season 22 Billy Crystal, Chris Russo, Chris Stapleton
- Season 22 Michael J. Fox, Iron & Wine, Ben Bridwell
- Season 22 Kevin James, Tom Dreesen, Tracy Chapman
- Season 22 Alec Baldwin, John Mayer
- Season 22 John Travolta, Amy Schumer, the Waterboys
- Season 22 Piedmont Bird Callers, Paul Rudd
- Season 22 Bruce Willis, Dawes
- Season 22 Robert Downey Jr., Chris Russo, Elvis Costello
- Season 22 Jerry Seinfeld, Jason Isbell & Amanda Shires
- Season 22 Scarlett Johansson, John Mellencamp, Todd Rundgren
- Season 22 Michael Keaton, Future Islands
- Season 22 Jack Hanna, John Popper
- Season 22 First Lady Michelle Obama Hootie and the Blowfish
- Season 22 Steve Martin, Emmylou Harris, Rodney Crowell, Amos Lee, Ralph Stanley, Mark O'Connor
- Season 22 President Barack Obama, Will Ferrell, the Avett Brothers, Brandi Carlile
- Season 22 Reese Witherspoon, Nathan Lane, Mumford & Sons
- Season 22 Martin Short, Norah Jones
- Season 22 Tina Fey, First Aid Kit
- Season 22 Ray Romano, Brian Regan, Dave Matthews Band
- Season 22 Howard Stern, Don Rickles
- Season 22 Bill Clinton, Adam Sandler
- Season 22 Julia Roberts, Paul Shaffer, Ryan Adams
- Season 22 Al Pacino, George Clooney, Tom Waits
- Season 22 Oprah Winfrey, Norm Macdonald
- Season 22 Tom Hanks, Eddie Vedder
- Season 22 Bill Murray, Bob Dylan
- Season 22 The Final Late Show with David Letterman
- Season 22 Episode 149
Late Show with David Letterman - Season 22 Episode 49 Seth Rogen, Amy Sedaris
6.37 63 minutes 
